Clearance of inflammatory cytokines in patients with septic acute kidney injury during renal replacement therapy using the EMiC2 filter (Clic-AKI study)

Abstract Background The EMiC2 membrane is a medium cut-off haemofilter (45 kiloDalton). Little known regarding its efficacy in eliminating medium-sized cytokines sepsis. This study aimed to explore the effects of continuous veno-venous haemodialysis (CVVHD) using filter on cytokine clearance. Methods was prospective observational conducted critically ill patients with sepsis and acute kidney injury requiring replacement therapy. We measured concentrations 12 [Interleukin (IL) IL-1?, IL-1?, IL-2, IL-4, IL-6, IL-8, IL-10, interferon (IFN)-?, tumour necrosis factor (TNF)-?, vascular endothelial growth factor, monocyte chemoattractant protein (MCP)-1, epidermal (EGF)] plasma at baseline (T0) pre- post-dialyzer 1, 6, 24, 48 h after CVVHD initiation effluent fluid corresponding time points. Outcomes were adsorptive clearance rates, mass balances, changes serial serum concentrations. Results Twelve included final analysis. All except EGF declined over ( p < 0.001). rates variable ranged from negligible values for IFN-?, EGF, 19.0 ml/min TNF-?. Negative or minimal adsorption observed. remained steady time. percentage removal low most throughout 48-h period. Conclusion EMiC2-CVVHD achieved modest demonstrated small no capacity despite decline suggests that may not be solely influenced by extracorporeal removal. Trial registration : NCT03231748, registered 27th July 2017.